SEED Subsystem: Isoleucine degradation in Pseudomonas putida KT2440

Experiments:

Role Gene Name L-Valine (C)  
⨯
3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) PP_2047 +0.2
  PP_2136 +0.0
3-ketoacyl-CoA thiolase (EC 2.3.1.16) PP_3355 +0.1
3-ketoacyl-CoA thiolase [isoleucine degradation] (EC 2.3.1.16) No genes
Acyl-CoA dehydrogenase, short-chain specific (EC 1.3.99.2) PP_2039 +0.1
  PP_3226 -0.0
Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12) No genes
Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit (EC 1.2.4.4) PP_4401 -4.5
Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit (EC 1.2.4.4) PP_4402 -4.0
Branched-chain amino acid aminotransferase (EC 2.6.1.42) PP_3511 -6.6
Butyrate kinase (EC 2.7.2.7) No genes
Butyryl-CoA dehydrogenase (EC 1.3.99.2) PP_1893 +0.1
  PP_2216 -0.3
  PP_2793 +0.4
  PP_3638 +0.1
  PP_3725 +0.2
Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.168) PP_4403 -4.4
Dihydrolipoamide dehydrogenase of branched-chain alpha-keto acid dehydrogenase (EC 1.8.1.4) PP_4404 -4.2
Enoyl-CoA hydratase (EC 4.2.1.17) PP_1412 +0.2
  PP_2047 +0.2
  PP_2136 +0.0
  PP_3726 -0.2
  PP_3732 +0.5
Enoyl-CoA hydratase [isoleucine degradation] (EC 4.2.1.17) No genes
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.-) No genes
Predicted transcriptional regulator of leucine degradation pathway, MerR family No genes
Probable acyl-CoA dehydrogenase (EC 1.3.99.3) PP_2214 -2.9
Transcriptional regulator BkdR of isoleucine and valine catabolism operon PP_4400 -6.2
phosphotransbutyrylase (EC 2.3.1.19) No genes

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