SEED Subsystem: Leucine Degradation and HMG-CoA Metabolism in Pseudomonas putida KT2440

Experiments:

Role Gene Name L-Leucine (C)  
⨯
Acetoacetyl-CoA synthetase (EC 6.2.1.16) PP_3071 -0.3
  PP_3458 -0.0
Acetoacetyl-CoA synthetase [leucine] (EC 6.2.1.16) No genes
Biotin carboxyl carrier protein of methylcrotonyl-CoA carboxylase No genes
Biotin carboxylase of methylcrotonyl-CoA carboxylase (EC 6.3.4.14) No genes
Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12) No genes
Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit (EC 1.2.4.4) PP_4401 -1.0
Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit (EC 1.2.4.4) PP_4402 -0.9
Branched-chain amino acid aminotransferase (EC 2.6.1.42) PP_3511 -4.7
Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.168) PP_4403 -1.8
Dihydrolipoamide dehydrogenase (EC 1.8.1.4) PP_5366 +0.1
Dihydrolipoamide dehydrogenase of branched-chain alpha-keto acid dehydrogenase (EC 1.8.1.4) PP_4404 +1.6
Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) PP_3393 -0.3
  PP_3394 +0.0
  PP_3540 N.D.
Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.34) No genes
Hydroxymethylglutaryl-CoA synthase (EC 2.3.3.10) No genes
Isovaleryl-CoA dehydrogenase (EC 1.3.99.10) No genes
Leucine dehydrogenase (EC 1.4.1.9) PP_4617 +0.0
Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4) PP_4067 -1.7
Methylcrotonyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.4) PP_4065 -2.9
Methylglutaconyl-CoA hydratase (EC 4.2.1.18) PP_4066 -1.5
Predicted transcriptional regulator of leucine degradation pathway, MerR family No genes
Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A (EC 2.8.3.5) PP_3122 -0.9
Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B (EC 2.8.3.5) PP_3123 -0.8

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