MetaCyc Pathway: superpathway of fatty acid biosynthesis I (E. coli) in Pseudomonas fluorescens GW456-L13

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[Acyl-carrier-protein] S-acetyltransferase:
acetyl-CoA + a soluble [acyl-carrier protein]→an acetyl-[acp] + coenzyme A
(EC 2.3.1.38)
No genes
acetyl-CoA + a [carboxyl-carrier protein dimer]-N6-carboxybiotinyl-L-lysine→malonyl-CoA + a [biotin carboxyl-carrier-protein dimer]-N6-biotinyl-L-lysine (EC 2.1.3.15)
PfGW456L13_3939
PfGW456L13_4692
[Acyl-carrier-protein] S-malonyltransferase:
malonyl-CoA + a soluble [acyl-carrier protein]→a malonyl-[acp] + coenzyme A
(EC 2.3.1.39)
PfGW456L13_1034
PfGW456L13_2104
Beta-ketoacyl-acyl-carrier-protein synthase III:
acetyl-CoA + a malonyl-[acp] + H+→an acetoacetyl-[acp] + CO2 + coenzyme A
(EC 2.3.1.180)
PfGW456L13_4365
PfGW456L13_4465
Beta-ketoacyl-acyl-carrier-protein synthase II:
an acetyl-[acp] + a malonyl-[acp] + H+→an acetoacetyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
PfGW456L13_2040
PfGW456L13_2107
PfGW456L13_2194
PfGW456L13_250
PfGW456L13_253
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxoacyl-[acyl-carrier protein] + NADPH + H+→a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
(EC 1.1.1.100)
PfGW456L13_1761
PfGW456L13_2105
PfGW456L13_2119
PfGW456L13_2345
PfGW456L13_2496
PfGW456L13_252
PfGW456L13_2520
PfGW456L13_2522
PfGW456L13_30
PfGW456L13_3401
PfGW456L13_3418
PfGW456L13_3421
PfGW456L13_3426
PfGW456L13_3433
PfGW456L13_3458
PfGW456L13_3461
PfGW456L13_3464
PfGW456L13_3610
PfGW456L13_3752
PfGW456L13_388
PfGW456L13_4129
PfGW456L13_437
PfGW456L13_4657
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyacyl-[acyl-carrier protein]→a trans-2-enoyl-[acyl-carrier protein] + H2O
(EC 4.2.1.59)
PfGW456L13_2041
PfGW456L13_4697
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxydecanoyl-[acp]→a (2E)-dec-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
PfGW456L13_2041
PfGW456L13_4697
Trans-2-decenoyl-[acyl-carrier-protein] isomerase:
a (2E)-dec-2-enoyl-[acp]→a (3Z)-dec-3-enoyl-[acp]
(EC 5.3.3.14)
PfGW456L13_2041
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a trans-2-enoyl-[acyl-carrier protein] + NADH + H+→a 2,3,4-saturated fatty acyl-[acp] + NAD+
(EC 1.3.1.9)
PfGW456L13_2534
PfGW456L13_2912
PfGW456L13_3347
PfGW456L13_3413
Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) (in reverse):
a trans-2-enoyl-[acyl-carrier protein] + NADPH + H+→a 2,3,4-saturated fatty acyl-[acp] + NADP+
(EC 1.3.1.10; 1.3.1.104; 1.3.1.39)
PfGW456L13_3347
Beta-ketoacyl-acyl-carrier-protein synthase II:
a 2,3,4-saturated fatty acyl-[acp] + a malonyl-[acp] + H+→a 3-oxoacyl-[acyl-carrier protein] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
PfGW456L13_2040
PfGW456L13_2107
PfGW456L13_2194
PfGW456L13_250
PfGW456L13_253
Beta-ketoacyl-acyl-carrier-protein synthase II:
a (3Z)-dec-3-enoyl-[acp] + a malonyl-[acp] + H+→a (5Z)-3-oxododec-5-enoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
PfGW456L13_2040
PfGW456L13_2107
PfGW456L13_2194
PfGW456L13_250
PfGW456L13_253
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a (5Z)-3-oxododec-5-enoyl-[acp] + NADPH + H+→a (3R,5Z)-3-hydroxydodec-5-enoyl-[acp] + NADP+
(EC 1.1.1.100)
PfGW456L13_1761
PfGW456L13_2105
PfGW456L13_2119
PfGW456L13_2345
PfGW456L13_2496
PfGW456L13_252
PfGW456L13_2520
PfGW456L13_2522
PfGW456L13_30
PfGW456L13_3401
PfGW456L13_3418
PfGW456L13_3421
PfGW456L13_3426
PfGW456L13_3433
PfGW456L13_3458
PfGW456L13_3461
PfGW456L13_3464
PfGW456L13_3610
PfGW456L13_3752
PfGW456L13_388
PfGW456L13_4129
PfGW456L13_437
PfGW456L13_4657
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R,5Z)-3-hydroxydodec-5-enoyl-[acp]→a (2E,5Z)-dodeca-3,5-dienoyl-[acp] + H2O
(EC 4.2.1.59)
PfGW456L13_2041
PfGW456L13_4697
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E,5Z)-dodeca-3,5-dienoyl-[acp] + NADH + H+→a (5Z)-dodec-5-enoyl-[acp] + NAD+
(EC 1.3.1.9)
PfGW456L13_2534
PfGW456L13_2912
PfGW456L13_3347
PfGW456L13_3413

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information