MetaCyc Pathway: valproate β-oxidation in Pseudomonas fluorescens GW456-L13

Add experiment(s):


Butyrate--CoA ligase:
valproate + ATP + coenzyme A→valproyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
valproyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-2-propylpent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
PfGW456L13_2983
PfGW456L13_2985
Enoyl-CoA hydratase (in reverse):
(2E)-2-propylpent-2-enoyl-CoA + H2O→(3S)-3-hydroxy-2-propylpentanoyl-CoA (EC 4.2.1.17)
PfGW456L13_1812
PfGW456L13_2246
PfGW456L13_2412
PfGW456L13_2433
PfGW456L13_2434
PfGW456L13_2533
PfGW456L13_2535
PfGW456L13_2984
PfGW456L13_2986
PfGW456L13_3210
PfGW456L13_3244
PfGW456L13_3388
PfGW456L13_3427
PfGW456L13_3636
PfGW456L13_4041
PfGW456L13_412
PfGW456L13_4142
PfGW456L13_4146
PfGW456L13_4531
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxy-2-propylpentanoyl-CoA + NAD+→3-oxo-2-propylpentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
PfGW456L13_1094
PfGW456L13_3395
PfGW456L13_4041
PfGW456L13_412
PfGW456L13_4146
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-2-propylpentanoyl-CoA + coenzyme A→pentanoyl-CoA + propanoyl-CoA (EC 2.3.1.16)
PfGW456L13_2157
PfGW456L13_2411
PfGW456L13_2430
PfGW456L13_2498
PfGW456L13_2538
PfGW456L13_2539
PfGW456L13_29
PfGW456L13_2982
PfGW456L13_3394
PfGW456L13_3408
PfGW456L13_4040
PfGW456L13_4147
PfGW456L13_4590
pentanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-pent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)
PfGW456L13_224
(2E)-pent-2-enoyl-CoA + H2O→(3S)-3-hydroxypentanoyl-CoA
No genes
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxypentanoyl-CoA + NAD+→3-oxopentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
PfGW456L13_1094
PfGW456L13_3395
PfGW456L13_4041
PfGW456L13_412
PfGW456L13_4146
Acetyl-CoA C-acyltransferase (in reverse):
3-oxopentanoyl-CoA + coenzyme A→propanoyl-CoA + acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
PfGW456L13_2157
PfGW456L13_2411
PfGW456L13_2430
PfGW456L13_2498
PfGW456L13_2538
PfGW456L13_2539
PfGW456L13_29
PfGW456L13_2982
PfGW456L13_3394
PfGW456L13_3408
PfGW456L13_4040
PfGW456L13_4147
PfGW456L13_4590

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information