MetaCyc Pathway: superpathway of L-tyrosine biosynthesis in Pseudomonas fluorescens GW456-L13

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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
PfGW456L13_2224
PfGW456L13_2244
PfGW456L13_2883
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
PfGW456L13_275
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
PfGW456L13_1428
PfGW456L13_4686
PfGW456L13_50
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
PfGW456L13_1427
PfGW456L13_2490
PfGW456L13_644
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
PfGW456L13_276
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
PfGW456L13_2178
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
PfGW456L13_4165
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
PfGW456L13_2176
PfGW456L13_2709
Prephenate dehydrogenase:
prephenate + NAD+→3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (EC 1.3.1.12)
PfGW456L13_2178
Aspartate transaminase (in reverse):
3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
PfGW456L13_2059
PfGW456L13_2142
PfGW456L13_2177
PfGW456L13_2252
PfGW456L13_2943
PfGW456L13_2947
PfGW456L13_3163
PfGW456L13_3206
PfGW456L13_3261
PfGW456L13_3292
PfGW456L13_3363
PfGW456L13_3960
PfGW456L13_4175
PfGW456L13_4396
PfGW456L13_4856
PfGW456L13_4919
PfGW456L13_4930
PfGW456L13_4999
PfGW456L13_733
PfGW456L13_807

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information