MetaCyc Pathway: 8-amino-7-oxononanoate biosynthesis I in Pseudomonas fluorescens GW456-L13

Add experiment(s):


a malonyl-[acp] + S-adenosyl-L-methionine→a malonyl-[acp] methyl ester + S-adenosyl-L-homocysteine (EC 2.1.1.197)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase II:
a malonyl-[acp] + a malonyl-[acp] methyl ester + H+→a 3-oxoglutaryl-[acp] methyl ester + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
PfGW456L13_2040
PfGW456L13_2107
PfGW456L13_2194
PfGW456L13_250
PfGW456L13_253
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxoglutaryl-[acp] methyl ester + NADPH + H+→a (3R)-3-hydroxyglutaryl-[acp] methyl ester + NADP+ (EC 1.1.1.100)
PfGW456L13_1761
PfGW456L13_2105
PfGW456L13_2119
PfGW456L13_2345
PfGW456L13_2496
PfGW456L13_252
PfGW456L13_2520
PfGW456L13_2522
PfGW456L13_30
PfGW456L13_3401
PfGW456L13_3418
PfGW456L13_3421
PfGW456L13_3426
PfGW456L13_3433
PfGW456L13_3458
PfGW456L13_3461
PfGW456L13_3464
PfGW456L13_3610
PfGW456L13_3752
PfGW456L13_388
PfGW456L13_4129
PfGW456L13_437
PfGW456L13_4657
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyglutaryl-[acp] methyl ester→a (2E)-enoylglutaryl-[acp] methyl ester + H2O (EC 4.2.1.59)
PfGW456L13_2041
PfGW456L13_4697
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-enoylglutaryl-[acp] methyl ester + NADH + H+→a glutaryl-[acp] methyl ester + NAD+ (EC 1.3.1.9)
PfGW456L13_2534
PfGW456L13_2912
PfGW456L13_3347
PfGW456L13_3413
Beta-ketoacyl-acyl-carrier-protein synthase II:
a glutaryl-[acp] methyl ester + a malonyl-[acp] + H+→a 3-oxopimeloyl-[acp] methyl ester + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
PfGW456L13_2040
PfGW456L13_2107
PfGW456L13_2194
PfGW456L13_250
PfGW456L13_253
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxopimeloyl-[acp] methyl ester + NADPH + H+→a (3R)-3-hydroxypimeloyl-[acp] methyl ester + NADP+ (EC 1.1.1.100)
PfGW456L13_1761
PfGW456L13_2105
PfGW456L13_2119
PfGW456L13_2345
PfGW456L13_2496
PfGW456L13_252
PfGW456L13_2520
PfGW456L13_2522
PfGW456L13_30
PfGW456L13_3401
PfGW456L13_3418
PfGW456L13_3421
PfGW456L13_3426
PfGW456L13_3433
PfGW456L13_3458
PfGW456L13_3461
PfGW456L13_3464
PfGW456L13_3610
PfGW456L13_3752
PfGW456L13_388
PfGW456L13_4129
PfGW456L13_437
PfGW456L13_4657
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxypimeloyl-[acp] methyl ester→a (2E)-enoylpimeloyl-[acp] methyl ester + H2O (EC 4.2.1.59)
PfGW456L13_2041
PfGW456L13_4697
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-enoylpimeloyl-[acp] methyl ester + NADH + H+→a pimeloyl-[acp] methyl ester + NAD+ (EC 1.3.1.9)
PfGW456L13_2534
PfGW456L13_2912
PfGW456L13_3347
PfGW456L13_3413
a pimeloyl-[acp] methyl ester + H2O→a pimeloyl-[acp] + methanol + H+ (EC 3.1.1.85)
No genes
8-amino-7-oxononanoate synthase:
a pimeloyl-[acp] + L-alanine + H+→(8S)-8-amino-7-oxononanoate + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.47)
PfGW456L13_1148

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information