MetaCyc Pathway: L-histidine degradation III in Pseudomonas fluorescens GW456-L13

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Histidine ammonia-lyase:
L-histidine→urocanate + ammonium (EC 4.3.1.3)
PfGW456L13_242
PfGW456L13_320
PfGW456L13_321
Urocanate hydratase (in reverse):
urocanate + H2O→4-imidazolone-5-propanoate (EC 4.2.1.49)
PfGW456L13_326
Imidazolonepropionase:
4-imidazolone-5-propanoate + H2O→N-formimino-L-glutamate (EC 3.5.2.7)
PfGW456L13_317
Glutamate formimidoyltransferase (in reverse):
N-formimino-L-glutamate + a tetrahydrofolate→5-formimidoyltetrahydrofolate + L-glutamate (EC 2.1.2.5)
No genes
Formimidoyltetrahydrofolate cyclodeaminase:
5-formimidoyltetrahydrofolate + 2 H+→a 5,10-methenyltetrahydrofolate + ammonium (EC 4.3.1.4)
No genes
Methenyltetrahydrofolate cyclohydrolase:
a 5,10-methenyltetrahydrofolate + H2O→an N10-formyltetrahydrofolate + H+ (EC 3.5.4.9)
PfGW456L13_2550

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information