MetaCyc Pathway: glutathione-mediated detoxification I in Pseudomonas fluorescens GW456-L13

Add experiment(s):


Glutathione transferase:
RX + glutathione→a glutathione-S-conjugate + HX (EC 2.5.1.18)
PfGW456L13_1706
PfGW456L13_1835
PfGW456L13_1922
PfGW456L13_2053
PfGW456L13_2079
PfGW456L13_2465
PfGW456L13_2657
PfGW456L13_3576
PfGW456L13_3797
PfGW456L13_4925
PfGW456L13_4960
PfGW456L13_692
PfGW456L13_853
a glutathione-S-conjugate[in] + ATP[in] + H2O[in]→a glutathione-S-conjugate[out] + ADP[in] + H+[in] + phosphate[in] (EC 7.6.2.3)
No genes
a glutathione-S-conjugate + H2O→an (L-cysteinylglycine)-S-conjugate + L-glutamate (EC 3.4.19.13)
No genes
an (L-cysteinylglycine)-S-conjugate + H2O→an L-cysteine-S-conjugate + glycine (EC 3.4.13.23)
No genes
Cysteine-S-conjugate N-acetyltransferase:
an L-cysteine-S-conjugate + acetyl-CoA→a mercapturate + coenzyme A + H+ (EC 2.3.1.80)
No genes
Cysteine-S-conjugate beta-lyase:
an L-cysteine-S-conjugate→2-aminoprop-2-enoate + a thiol (EC 4.4.1.13)
No genes
Tryptophanase:
2-aminoprop-2-enoate→2-iminopropanoate (spontaneous) (EC 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)
PfGW456L13_1089
PfGW456L13_1867
PfGW456L13_2867
PfGW456L13_3549
PfGW456L13_3648
PfGW456L13_443
PfGW456L13_4954
2-iminopropanoate + H2O→pyruvate + ammonium (spontaneous) (EC 3.5.99.10; 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)
PfGW456L13_1089
PfGW456L13_1867
PfGW456L13_2867
PfGW456L13_3549
PfGW456L13_3648
PfGW456L13_443
PfGW456L13_4954
PfGW456L13_779

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information