MetaCyc Pathway: superpathway of the 3-hydroxypropanoate cycle in Xanthobacter sp. DMC5

Add experiment(s):


Carbonate dehydratase (in reverse):
CO2 + H2O→hydrogen carbonate + H+ (EC 4.2.1.1)
GFF2430
GFF263
GFF4733
GFF908
Biotin carboxylase:
hydrogen carbonate + ATP + a [biotin carboxyl-carrier-protein dimer]-N6-biotinyl-L-lysine→a [carboxyl-carrier protein dimer]-N6-carboxybiotinyl-L-lysine + ADP + H+ + phosphate (EC 6.3.4.14)
GFF235
GFF236
GFF3160
a [carboxyl-carrier protein dimer]-N6-carboxybiotinyl-L-lysine + acetyl-CoA→malonyl-CoA + a [biotin carboxyl-carrier-protein dimer]-N6-biotinyl-L-lysine (EC 2.1.3.15)
GFF2566
GFF3885
malonyl-CoA + NADPH + H+→3-oxopropanoate + coenzyme A + NADP+ (EC 1.2.1.75)
No genes
3-oxopropanoate + NADPH + H+→3-hydroxypropanoate + NADP+ (EC 1.1.1.298)
GFF2291
GFF4165
3-hydroxypropanoate + ATP + coenzyme A→3-hydroxypropanoyl-CoA + AMP + diphosphate (EC 6.2.1.36)
No genes
3-hydroxypropanoyl-CoA→acryloyl-CoA + H2O (EC 4.2.1.116)
GFF2039
GFF2845
GFF4546
acryloyl-CoA + NADPH + H+→propanoyl-CoA + NADP+ (EC 1.3.1.84)
GFF3340
Propionyl-CoA carboxylase:
hydrogen carbonate + propanoyl-CoA + ATP→(S)-methylmalonyl-CoA + ADP + H+ + phosphate (EC 6.4.1.3)
GFF2566
GFF3160
GFF3161
GFF3885
Malyl-CoA lyase (in reverse):
propanoyl-CoA + glyoxylate→(2R,3S)-β-methylmalyl-CoA (EC 4.1.3.24)
GFF612
Methylmalonyl-CoA epimerase (in reverse):
(S)-methylmalonyl-CoA→(R)-methylmalonyl-CoA (EC 5.1.99.1)
GFF1234
(2R,3S)-β-methylmalyl-CoA→2-methylfumaryl-CoA + H2O (EC 4.2.1.148)
No genes
Methylmalonyl-CoA mutase:
(R)-methylmalonyl-CoA→succinyl-CoA (EC 5.4.99.2)
GFF3155
GFF3157
2-methylfumaryl-CoA→3-methylfumaryl-CoA (EC 5.4.1.3)
No genes
succinyl-CoA + (S)-malate→(S)-malyl-CoA + succinate (EC 2.8.3.22)
No genes
3-methylfumaryl-CoA + H2O→(3S)-citramalyl-CoA (EC 4.2.1.153)
No genes
Citramalyl-CoA lyase:
(3S)-citramalyl-CoA→acetyl-CoA + pyruvate (EC 4.1.3.25)
GFF612
Malyl-CoA lyase:
(S)-malyl-CoA→acetyl-CoA + glyoxylate (EC 4.1.3.24)
GFF612

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information