MetaCyc Pathway: sphingosine and sphingosine-1-phosphate metabolism in Pseudomonas simiae WCS417

Add experiment(s):


Ceramidase:
an N-acylsphingosine + H2O→sphingosine + a fatty acid (EC 3.5.1.23)
No genes
Sphinganine kinase:
sphingosine + ATP→sphingosine 1-phosphate + ADP + H+ (EC 2.7.1.91)
No genes
sphingosine 1-phosphate + H2O→sphingosine + phosphate
No genes
sphingosine 1-phosphate→(2E)-hexadecenal + O-phosphoethanolamine
No genes
2-hexadecenal reductase (in reverse):
(2E)-hexadecenal + NADPH + H+→hexadecanal + NADP+ (EC 1.3.1.27)
No genes
Aldehyde dehydrogenase (NAD(+)):
(2E)-hexadecenal + NAD+ + H2O→(2E)-hexadecenoate + NADH + 2 H+ (EC 1.2.1.3)
PS417_07290
PS417_11170
PS417_14675
PS417_17430
PS417_18205
PS417_24810
PS417_02645
PS417_26845
PS417_27745
PS417_04200
Aldehyde dehydrogenase (NAD(+)):
hexadecanal + NAD+ + H2O→palmitate + NADH + 2 H+ (EC 1.2.1.3)
PS417_07290
PS417_11170
PS417_14675
PS417_17430
PS417_18205
PS417_24810
PS417_02645
PS417_26845
PS417_27745
PS417_04200
Long-chain-fatty-acid--CoA ligase:
(2E)-hexadecenoate + ATP + coenzyme A→(2E)-hexadec-2-enoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
PS417_15170
PS417_17010
PS417_19290
PS417_22065
PS417_22070
Acyl-CoA dehydrogenase (NADP(+)) (in reverse):
(2E)-hexadec-2-enoyl-CoA + NADPH + H+→palmitoyl-CoA + NADP+ (EC 1.3.1.8)
No genes
Long-chain-fatty-acid--CoA ligase:
palmitate + ATP + coenzyme A→palmitoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
PS417_15170
PS417_17010
PS417_19290
PS417_22065
PS417_22070

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information