MetaCyc Pathway: superpathway of L-citrulline metabolism in Pseudomonas simiae WCS417

Add experiment(s):


Glutamate synthase (NADPH):
L-glutamine + H2O→L-glutamate + ammonia + H+
(EC 1.4.1.13; 1.4.1.14; 1.4.7.1; 2.6.1.85; 3.5.1.2; 3.5.1.38; 4.1.3.27; 4.3.2.10; 4.3.3.6; 6.3.4.2; 6.3.5.13; 6.3.5.2; 6.3.5.4; 6.3.5.5; 6.3.5.6; 6.3.5.7)
PS417_05250
PS417_05415
PS417_06300
PS417_06580
PS417_06685
PS417_08425
PS417_11435
PS417_15505
PS417_16695
PS417_17275
PS417_17325
PS417_17690
PS417_17915
PS417_18410
PS417_19230
PS417_19985
PS417_02000
PS417_02005
PS417_21105
PS417_21210
PS417_21855
PS417_22155
PS417_22930
PS417_23070
PS417_24040
PS417_24045
PS417_25280
PS417_25720
PS417_25725
PS417_28355
PS417_04235
PS417_04240
PS417_04245
Carbamoyl-phosphate synthase (ammonia):
ammonium + 2 ATP + hydrogen carbonate→carbamoyl phosphate + 2 ADP + 2 H+ + phosphate
(EC 6.3.4.16)
No genes
L-proline[in] + an electron-transfer quinone→(S)-1-pyrroline-5-carboxylate[in] + an electron-transfer quinol + H+[in] (EC 1.5.5.2)
PS417_02175
Glutamate 5-kinase:
L-glutamate + ATP→γ-L-glutamyl 5-phosphate + ADP
(EC 2.7.2.11)
PS417_23545
(S)-1-pyrroline-5-carboxylate + H+ + H2O→L-glutamate 5-semialdehyde (spontaneous)
No genes
Glutamate-5-semialdehyde dehydrogenase (in reverse):
γ-L-glutamyl 5-phosphate + NADPH + H+→L-glutamate 5-semialdehyde + NADP+ + phosphate
(EC 1.2.1.41)
PS417_24745
Ornithine aminotransferase (in reverse):
L-glutamate + L-glutamate 5-semialdehyde→L-ornithine + 2-oxoglutarate
(EC 2.6.1.13)
PS417_21710
PS417_25950
Ornithine carbamoyltransferase:
L-ornithine + carbamoyl phosphate→L-citrulline + H+ + phosphate
(EC 2.1.3.3)
PS417_05595
PS417_22335
Argininosuccinate synthase:
L-citrulline + ATP + L-aspartate→L-arginino-succinate + AMP + diphosphate + H+
(EC 6.3.4.5)
PS417_05640
Argininosuccinate lyase:
L-arginino-succinate→L-arginine + fumarate
(EC 4.3.2.1)
PS417_21780
PS417_27540
Arginase:
L-arginine + H2O→L-ornithine + urea
(EC 3.5.3.1)
PS417_05475
Nitric-oxide synthase:
2 L-arginine + 3 NADPH + 4 dioxygen + H+→2 L-citrulline + 3 NADP+ + 2 nitric oxide + 4 H2O
(EC 1.14.13.39)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information