MetaCyc Pathway: sphingosine and sphingosine-1-phosphate metabolism in Variovorax sp. SCN45

Add experiment(s):


Ceramidase:
an N-acylsphingosine + H2O→sphingosine + a fatty acid (EC 3.5.1.23)
No genes
Sphinganine kinase:
sphingosine + ATP→sphingosine 1-phosphate + ADP + H+ (EC 2.7.1.91)
No genes
sphingosine 1-phosphate + H2O→sphingosine + phosphate
No genes
sphingosine 1-phosphate→(2E)-hexadecenal + O-phosphoethanolamine
No genes
2-hexadecenal reductase (in reverse):
(2E)-hexadecenal + NADPH + H+→hexadecanal + NADP+ (EC 1.3.1.27)
No genes
Aldehyde dehydrogenase (NAD(+)):
(2E)-hexadecenal + NAD+ + H2O→(2E)-hexadecenoate + NADH + 2 H+ (EC 1.2.1.3)
GFF1127
GFF1479
GFF1561
GFF1621
GFF2220
GFF2906
GFF4162
GFF4332
GFF4409
GFF5027
GFF5192
GFF5612
GFF5830
GFF5850
GFF6147
GFF6191
GFF6442
GFF6752
GFF7390
Aldehyde dehydrogenase (NAD(+)):
hexadecanal + NAD+ + H2O→palmitate + NADH + 2 H+ (EC 1.2.1.3)
GFF1127
GFF1479
GFF1561
GFF1621
GFF2220
GFF2906
GFF4162
GFF4332
GFF4409
GFF5027
GFF5192
GFF5612
GFF5830
GFF5850
GFF6147
GFF6191
GFF6442
GFF6752
GFF7390
Long-chain-fatty-acid--CoA ligase:
(2E)-hexadecenoate + ATP + coenzyme A→(2E)-hexadec-2-enoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
GFF2007
GFF3496
GFF3611
GFF3786
GFF6538
GFF7283
Acyl-CoA dehydrogenase (NADP(+)) (in reverse):
(2E)-hexadec-2-enoyl-CoA + NADPH + H+→palmitoyl-CoA + NADP+ (EC 1.3.1.8)
No genes
Long-chain-fatty-acid--CoA ligase:
palmitate + ATP + coenzyme A→palmitoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
GFF2007
GFF3496
GFF3611
GFF3786
GFF460
GFF6538
GFF7283

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information