MetaCyc Pathway: representative whole plasma arachidonate-derived icosanoids II in Variovorax sp. SCN45

Add experiment(s):


Sterol esterase:
CE(20:4) + H2O→arachidonate + cholesterol + H+ (EC 3.1.1.13)
No genes
Phospholipase A(2):
PE(18:0/20:4) + H2O→arachidonate + 1-stearoyl-sn-glycero-3-phosphoethanolamine + H+ (EC 3.1.1.4)
No genes
Phospholipase A(2):
PC(16:0/20:4) + H2O→arachidonate + 1-palmitoyl-sn-glycero-3-phosphocholine + H+ (EC 3.1.1.4)
No genes
Phospholipase A(2):
PC(18:0/20:4) + H2O→arachidonate + 1-stearoyl-sn-glycero-3-phosphocholine + H+ (EC 3.1.1.4)
No genes
Phospholipase A(2):
PA(20:0/20:4) + H2O→arachidonate + 1-icosanoyl-sn-glycerol 3-phosphate + H+ (EC 3.1.1.4)
No genes
Phospholipase A(2):
PC ae (18:0/20:4) + H2O→arachidonate + 1-O-octadecanoyl-sn-glycero-3-phosphocholine + H+ (EC 3.1.1.4)
No genes
Phospholipase A(2):
PS(14:0/20:4) + H2O→arachidonate + 1-14:0-2-lysophosphatidylserine + H+ (EC 3.1.1.4)
No genes
Phospholipase A(2):
PG(20:4/20:4) + H2O→arachidonate + 1-arachidonyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H+ (EC 3.1.1.4)
No genes
Arachidonate 12-lipoxygenase:
arachidonate + dioxygen→(12S)-HpETE (EC 1.13.11.31)
No genes
Arachidonate 15-lipoxygenase:
arachidonate + dioxygen→(15S)-HpETE (EC 1.13.11.33)
GFF5228
Arachidonate 5-lipoxygenase:
arachidonate + dioxygen→(5S)-HpETE (EC 1.13.11.34)
No genes
Arachidonate 8-lipoxygenase:
arachidonate + dioxygen→(8S)-HpETE (EC 1.13.11.40)
No genes
Phospholipid-hydroperoxide glutathione peroxidase:
(12S)-HpETE + 2 glutathione→12(S)-HETE + glutathione disulfide + H2O (EC 1.11.1.12)
No genes
Phospholipid-hydroperoxide glutathione peroxidase:
(5S)-HpETE + 2 glutathione→5(S)-HETE + glutathione disulfide + H2O (EC 1.11.1.12)
No genes
Phospholipid-hydroperoxide glutathione peroxidase:
(8S)-HpETE + 2 glutathione→8(S)-HETE + glutathione disulfide + H2O (EC 1.11.1.12)
No genes
Phospholipid-hydroperoxide glutathione peroxidase:
(15S)-HpETE + 2 glutathione→15(S)-HETE + glutathione disulfide + H2O (EC 1.11.1.12)
No genes
15-hydroxyicosatetraenoate dehydrogenase:
15(S)-HETE + NAD(P)+→15-oxo-ETE + NAD(P)H + H+ (EC 1.1.1.232)
No genes
5(S)-HETE + NADP+→5-oxo-ETE + NADPH + H+ (EC 1.1.1.M76)
No genes
12(S)-HETE + NADP+→12-oxo-ETE + NADPH + H+
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information