Phospholipase A(2):
a [glycerolipid]-(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate + H2O→(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate + a glycerolipid + H+ (EC 3.1.1.4) |
| No genes |
Arachidonate 15-lipoxygenase:
(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate + dioxygen→15(S)-HpEPE (EC 1.13.11.33) |
| GFF5228 |
Arachidonate 12-lipoxygenase:
(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate + dioxygen→12(S)-HpEPE (EC 1.13.11.31) |
| No genes |
Arachidonate 5-lipoxygenase:
(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate + dioxygen→5(S)-HpEPE (EC 1.13.11.34) |
| No genes |
| (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate + dioxygen→leukotriene B5 |
| No genes |
Prostaglandin-endoperoxide synthase:
(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate + a reduced two electron carrier + 2 dioxygen→prostaglandin H3 + an oxidized electron carrier + H2O (EC 1.14.99.1) |
| No genes |
| (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate + dioxygen + a reduced [NADPH-hemoprotein reductase]→14(15)-EpETE + an oxidized [NADPH-hemoprotein reductase] + H2O |
| No genes |
| (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate + dioxygen + a reduced [NADPH-hemoprotein reductase]→17(18)-EpETE + an oxidized [NADPH-hemoprotein reductase] + H2O |
| No genes |
| (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate + a reduced two electron carrier + dioxygen→8-HEPE + an oxidized electron carrier + H2O (spontaneous) |
| No genes |
| (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate + a reduced two electron carrier + dioxygen→11-HEPE + an oxidized electron carrier + H2O (spontaneous) |
| No genes |
| (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate + a reduced two electron carrier + dioxygen→9-HEPE + an oxidized electron carrier + H2O (spontaneous) |
| No genes |
| (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate + a reduced two electron carrier + dioxygen→18-HEPE + an oxidized electron carrier + H2O (spontaneous) |
| No genes |
| (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate + a reduced two electron carrier + dioxygen→18(R)-HEPE + an oxidized electron carrier + H2O |
| No genes |
Phospholipid-hydroperoxide glutathione peroxidase:
15(S)-HpEPE + 2 glutathione→15(S)-HEPE + glutathione disulfide + H2O (EC 1.11.1.12) |
| No genes |
Phospholipid-hydroperoxide glutathione peroxidase:
12(S)-HpEPE + 2 glutathione→12(S)-HEPE + glutathione disulfide + H2O (EC 1.11.1.12) |
| No genes |
Phospholipid-hydroperoxide glutathione peroxidase:
5(S)-HpEPE + 2 glutathione→5(S)-HEPE + glutathione disulfide + H2O (EC 1.11.1.12) |
| No genes |
Prostaglandin-D synthase:
prostaglandin H3→prostaglandin D3 (EC 5.3.99.2) |
| No genes |
| prostaglandin H3 + a reduced thioredoxin→prostaglandin F3α + an oxidized thioredoxin (EC 1.11.1.20) |
| No genes |
Prostaglandin-E synthase:
prostaglandin H3→prostaglandin E3 (EC 5.3.99.3) |
| No genes |
Prostaglandin-I synthase:
prostaglandin H3→prostaglandin I3 (EC 5.3.99.4) |
| No genes |
Thromboxane-A synthase:
prostaglandin H3→thromboxane A3 (EC 5.3.99.5) |
| No genes |
Soluble epoxide hydrolase:
14(15)-EpETE + H2O→14,15-diHETE (EC 3.3.2.10) |
| No genes |
Soluble epoxide hydrolase:
17(18)-EpETE + H2O→17,18-diHETE (EC 3.3.2.10) |
| No genes |
| 18-HEPE + dioxygen→resolvin E1 |
| No genes |
Arachidonate 5-lipoxygenase:
18(R)-HEPE + dioxygen→(5S,18R)-18-hydroxy-5-hydroperoxyicosapentaenoate (EC 1.13.11.34) |
| No genes |
Arachidonate 5-lipoxygenase:
(5S,18R)-18-hydroxy-5-hydroperoxyicosapentaenoate→(7E,9E,11Z,14Z,18R,16E)-(5S,6S)-5,6-epoxyicosa-15-hydroxy-7,9,11,14,18-pentaenoate + H2O (EC 1.13.11.34) |
| No genes |
15-hydroxyprostaglandin dehydrogenase (NAD(+)):
prostaglandin F3α + NAD+→15-dehydro-prostaglandin F3α + NADH + H+ (EC 1.1.1.141) |
| No genes |
15-hydroxyprostaglandin dehydrogenase (NAD(+)):
prostaglandin E3 + NAD+→15-dehydro-prostaglandin E3 + NADH + H+ (EC 1.1.1.141) |
| No genes |
| prostaglandin I3 + H2O→Δ17-6-oxo-prostaglandin F1α |
| No genes |
| thromboxane A3 + H2O→thromboxane B3 |
| No genes |
15-oxoprostaglandin 13-oxidase (in reverse):
15-dehydro-prostaglandin F3α + NADPH + H+→15-dehydro-13,14-dihydro-prostaglandin F3α + NADP+ (EC 1.3.1.48) |
| No genes |
15-oxoprostaglandin 13-oxidase (in reverse):
15-dehydro-prostaglandin E3 + NAD(P)H + H+→15-dehydro-13,14-dihydro-prostaglandin E3 + NAD(P)+ (EC 1.3.1.48) |
| No genes |
Leukotriene-A(4) hydrolase:
(7E,9E,11Z,14Z,18R,16E)-(5S,6S)-5,6-epoxyicosa-15-hydroxy-7,9,11,14,18-pentaenoate + H2O→resolvin E1 (EC 3.3.2.6) |
| No genes |
| 15-dehydro-13,14-dihydro-prostaglandin F3α + a reduced two electron carrier→13,14-dihydro-prostaglandin F3α + an oxidized electron carrier |
| No genes |
| 15-dehydro-13,14-dihydro-prostaglandin E3 + a reduced two electron carrier→13,14-dihydro-prostaglandin E3 + an oxidized electron carrier |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information