MetaCyc Pathway: di-homo-γ-linolenate metabolites biosynthesis in Variovorax sp. SCN45

Add experiment(s):


Phospholipase A(2):
a [glycerolipid]-di-homo-γ-linolenate + H2O→di-homo-γ-linolenate + a glycerolipid + H+ (EC 3.1.1.4)
No genes
Arachidonate 15-lipoxygenase:
di-homo-γ-linolenate + dioxygen→15(S)-HpETrE (EC 1.13.11.33)
GFF5228
Prostaglandin-endoperoxide synthase:
di-homo-γ-linolenate + a reduced two electron carrier + 2 dioxygen→prostaglandin H1 + an oxidized electron carrier + H2O (EC 1.14.99.1)
No genes
Phospholipid-hydroperoxide glutathione peroxidase:
15(S)-HpETrE + 2 glutathione→15(S)-HETrE + glutathione disulfide + H2O (EC 1.11.1.12)
No genes
Prostaglandin-D synthase:
prostaglandin H1→prostaglandin D1 (EC 5.3.99.2)
No genes
prostaglandin H1 + a reduced thioredoxin→prostaglandin F1α + an oxidized thioredoxin (EC 1.11.1.20)
No genes
Prostaglandin-E synthase:
prostaglandin H1→prostaglandin E1 (EC 5.3.99.3)
No genes
Thromboxane-A synthase:
prostaglandin H1→thromboxane A1 (EC 5.3.99.5)
No genes
15-hydroxyprostaglandin dehydrogenase (NADP(+)):
prostaglandin E1 + NADP+→15-dehydro-prostaglandin E1 + NADPH + H+ (EC 1.1.1.197)
No genes
prostaglandin D1→15-dehydro-13,14-dihydro-prostaglandin E1
No genes
15-hydroxyprostaglandin dehydrogenase (NAD(+)):
prostaglandin F1α + NAD+→15-dehydro-prostaglandin F1α + NADH + H+ (EC 1.1.1.141)
No genes
thromboxane A1 + H2O→thromboxane B1
No genes
15-oxoprostaglandin 13-oxidase (in reverse):
15-dehydro-prostaglandin F1α + NADPH + H+→15-dehydro-13,14-dihydro-prostaglandin F1α + NADP+ (EC 1.3.1.48)
No genes
15-oxoprostaglandin 13-oxidase (in reverse):
15-dehydro-prostaglandin E1 + NADPH + H+→15-dehydro-13,14-dihydro-prostaglandin E1 + NADP+ (EC 1.3.1.48)
No genes
15-dehydro-13,14-dihydro-prostaglandin F1α + NADPH + H+→13,14-dihydro-prostaglandin F1α + NADP+
No genes
15-dehydro-13,14-dihydro-prostaglandin E1 + NADPH + H+→13,14-dihydro-prostaglandin E1 + NADP+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information