MetaCyc Pathway: mevalonate degradation in Variovorax sp. SCN45

Hydroxymethylglutaryl-CoA reductase:
(R)-mevalonate + coenzyme A + 2 NAD⁺→(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H⁺ (EC 1.1.1.88)

GFF3373

Hydroxymethylglutaryl-CoA lyase:
(S)-3-hydroxy-3-methylglutaryl-CoA→acetoacetate + acetyl-CoA (EC 4.1.3.4)

GFF2023

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Pathway details at MetaCyc
Fitness data for 9 genes
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All MetaCyc pathways for Variovorax sp. SCN45

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information