MetaCyc Pathway: superpathway of L-citrulline metabolism in Variovorax sp. SCN45

Add experiment(s):


Glutamate synthase (NADPH):
L-glutamine + H2O→L-glutamate + ammonia + H+ (EC 1.4.1.13; 1.4.1.14; 1.4.7.1; 2.6.1.85; 3.5.1.2; 3.5.1.38; 4.1.3.27; 4.3.2.10; 4.3.3.6; 6.3.4.2; 6.3.5.13; 6.3.5.2; 6.3.5.4; 6.3.5.5; 6.3.5.6; 6.3.5.7)
GFF1457
GFF1473
GFF1880
GFF194
GFF1977
GFF206
GFF2338
GFF2417
GFF2419
GFF2453
GFF2751
GFF3469
GFF3490
GFF376
GFF377
GFF394
GFF4130
GFF5061
GFF5062
GFF5063
GFF5332
GFF5333
GFF5374
GFF5894
GFF5896
GFF5959
GFF6278
GFF6781
GFF6827
GFF7707
GFF7814
GFF7905
Carbamoyl-phosphate synthase (ammonia):
ammonium + 2 ATP + hydrogen carbonate→carbamoyl phosphate + 2 ADP + 2 H+ + phosphate (EC 6.3.4.16)
No genes
L-proline[in] + an electron-transfer quinone→(S)-1-pyrroline-5-carboxylate[in] + an electron-transfer quinol + H+[in] (EC 1.5.5.2)
No genes
Glutamate 5-kinase:
L-glutamate + ATP→γ-L-glutamyl 5-phosphate + ADP (EC 2.7.2.11)
GFF2515
(S)-1-pyrroline-5-carboxylate + H+ + H2O→L-glutamate 5-semialdehyde (spontaneous)
No genes
Glutamate-5-semialdehyde dehydrogenase (in reverse):
γ-L-glutamyl 5-phosphate + NADPH + H+→L-glutamate 5-semialdehyde + NADP+ + phosphate (EC 1.2.1.41)
GFF6326
Ornithine aminotransferase (in reverse):
L-glutamate + L-glutamate 5-semialdehyde→L-ornithine + 2-oxoglutarate (EC 2.6.1.13)
No genes
Ornithine carbamoyltransferase:
L-ornithine + carbamoyl phosphate→L-citrulline + H+ + phosphate (EC 2.1.3.3)
GFF3926
GFF6948
Argininosuccinate synthase:
L-citrulline + ATP + L-aspartate→L-arginino-succinate + AMP + diphosphate + H+ (EC 6.3.4.5)
GFF3096
Argininosuccinate lyase:
L-arginino-succinate→L-arginine + fumarate (EC 4.3.2.1)
GFF1697
GFF3824
Arginase:
L-arginine + H2O→L-ornithine + urea (EC 3.5.3.1)
GFF3772
Nitric-oxide synthase:
2 L-arginine + 3 NADPH + 4 dioxygen + H+→2 L-citrulline + 3 NADP+ + 2 nitric oxide + 4 H2O (EC 1.14.13.39)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information