MetaCyc Pathway: ketogenesis in Variovorax sp. OAS795

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Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
ABID97_RS04675
ABID97_RS05875
ABID97_RS06005
ABID97_RS10975
ABID97_RS11335
ABID97_RS11380
ABID97_RS12420
ABID97_RS15750
ABID97_RS18615
ABID97_RS18775
ABID97_RS20240
ABID97_RS24190
ABID97_RS25195
ABID97_RS26575
ABID97_RS27835
ABID97_RS28230
ABID97_RS28270
ABID97_RS28430
Hydroxymethylglutaryl-CoA synthase:
acetoacetyl-CoA + acetyl-CoA + H2O→(S)-3-hydroxy-3-methylglutaryl-CoA + coenzyme A + H+ (EC 2.3.3.10)
ABID97_RS18620
Hydroxymethylglutaryl-CoA lyase:
(S)-3-hydroxy-3-methylglutaryl-CoA→acetyl-CoA + acetoacetate (EC 4.1.3.4)
ABID97_RS04725
ABID97_RS04730
ABID97_RS10505
ABID97_RS10510
ABID97_RS19460
ABID97_RS25100
3-hydroxybutyrate dehydrogenase (in reverse):
acetoacetate + NADH + H+→(R)-3-hydroxybutanoate + NAD+ (EC 1.1.1.30)
ABID97_RS01060
ABID97_RS01945
ABID97_RS08920
ABID97_RS14375
ABID97_RS17250
ABID97_RS19570
Acetoacetate decarboxylase:
acetoacetate + H+→acetone + CO2 (EC 4.1.1.4)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information