MetaCyc Pathway: polyhydroxybutanoate biosynthesis in Variovorax sp. OAS795

MetaCyc Pathway: polyhydroxybutanoate biosynthesis in Variovorax sp. OAS795

Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)

Acetoacetyl-CoA reductase (in reverse):
acetoacetyl-CoA + NADPH + H⁺→(3R)-3-hydroxybutanoyl-CoA + NADP⁺ (EC 1.1.1.36)

(3R)-3-hydroxybutanoyl-CoA + poly-[(R)-3-hydroxybutanoate]→poly-[(R)-3-hydroxybutanoate] + coenzyme A (EC 2.3.1.304)

Links:

Pathway details at MetaCyc
Fitness data for 21 genes
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All MetaCyc pathways for Variovorax sp. OAS795

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information