MetaCyc Pathway: (2<i>S</i>)-ethylmalonyl-CoA biosynthesis in Variovorax sp. OAS795

MetaCyc Pathway: (2S)-ethylmalonyl-CoA biosynthesis in Variovorax sp. OAS795

Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)

Acetoacetyl-CoA reductase (in reverse):
acetoacetyl-CoA + NADPH + H⁺→(3R)-3-hydroxybutanoyl-CoA + NADP⁺ (EC 1.1.1.36)

3-hydroxybutyryl-CoA dehydratase:
(3R)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H₂O (EC 4.2.1.55)

crotonyl-CoA + CO₂ + NADPH→(2S)-ethylmalonyl-CoA + NADP⁺ (EC 1.3.1.85)

No genes

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Pathway details at MetaCyc
Fitness data for 22 genes
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All MetaCyc pathways for Variovorax sp. OAS795

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information