MetaCyc Pathway: antimycin biosynthesis in Variovorax sp. OAS795

Add experiment(s):


anthranilate + ATP + a holo [AntG acyl-carrier protein]→an anthraniloyl-[AntG acyl-carrier protein] + AMP + diphosphate
No genes
L-threonine + ATP + an [AntC non-ribosomal peptide synthase]→an L-threonyl-[AntC non-ribosomal peptide synthase] + AMP + diphosphate (EC 6.2.1.70)
No genes
pyruvate + ATP + an [AntC non-ribosomal peptide synthase]→pyruvoyl-[AntC non-ribosomal peptide synthase] + AMP + diphosphate
No genes
a (2E)-2-enoyl-CoA + CO2 + NADPH→a 2-carboxy-CoA + NADP+
No genes
an anthraniloyl-[AntG acyl-carrier protein] + NADPH + dioxygen + H+→a 1,2-epoxyanthraniloyl-[AntG acyl-carrier protein] + NADP+ + H2O
ABID97_RS22800
a 1,2-epoxyanthraniloyl-[AntG acyl-carrier protein]→3-aminosalicyl-[AntG acyl-carrier protein] (spontaneous)
No genes
3-aminosalicyl-[AntG acyl-carrier protein] + an N10-formyltetrahydrofolate→3-formamidosalicyl-[AntG acyl-carrier protein] + a tetrahydrofolate
No genes
3-formamidosalicyl-[AntG acyl-carrier protein] + an L-threonyl-[AntC non-ribosomal peptide synthase]→antimycin intermediate 1-[AntC non-ribosomal peptide synthase] + a holo [AntG acyl-carrier protein] + H+
No genes
antimycin intermediate 1-[AntC non-ribosomal peptide synthase] + pyruvoyl-[AntC non-ribosomal peptide synthase] + NADPH + H+→antimycin intermediate 2-[AntC non-ribosomal peptide synthase] + an [AntC non-ribosomal peptide synthase] + NADP+
No genes
a 2-carboxy-CoA + antimycin intermediate 2-[AntC non-ribosomal peptide synthase] + a holo [AntD polyketide synthase] + H+→antimycin intermediate 3-[AntD polyketide synthase] + an [AntC non-ribosomal peptide synthase] + CO2 + coenzyme A
No genes
antimycin intermediate 3-[AntD polyketide synthase] + NADPH + H+→antimycin intermediate 4-[AntD polyketide synthase] + NADP+
No genes
antimycin intermediate 4-[AntD polyketide synthase]→a C8-hydroxy antimycin + a holo [AntD polyketide synthase]
No genes
a C8-hydroxy antimycin + an acyl-CoA→an antimycin + coenzyme A (EC 2.3.1.M107)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information