MetaCyc Pathway: picolinate degradation in Variovorax sp. OAS795

MetaCyc Pathway: picolinate degradation in Variovorax sp. OAS795

picolinate + an oxidized electron carrier + H₂O→6-hydroxypicolinate + a reduced two electron carrier

6-hydroxypicolinate + NADH + dioxygen + H⁺→3,6-dihydroxypicolinate + NAD⁺ + H₂O

3,6-dihydroxypicolinate + H⁺→2,5-dihydroxypyridine + CO₂

2,5-dihydroxypyridine 5,6-dioxygenase:
2,5-dihydroxypyridine + dioxygen→N-formylmaleamate + H⁺ (EC 1.13.11.9)

N-formylmaleamate + H₂O→maleamate + formate + H⁺ (EC 3.5.1.106)

maleamate + H₂O→maleate + ammonium (EC 3.5.1.107)

Maleate isomerase:
maleate→fumarate (EC 5.2.1.1)

No genes

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Pathway details at MetaCyc
Fitness data for 9 genes
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All MetaCyc pathways for Variovorax sp. OAS795

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information