| acetyl-CoA + 9 malonyl-CoA + 9 H+ + a holo acp domain within a [polyketide synthase]→3,5,7,9,11,13,15,17,19-nonaoxoicosanoyl-[PKS-acp] + 9 CO2 + 10 coenzyme A |
| No genes |
| 3,5,7,9,11,13,15,17,19-nonaoxoicosanoyl-[PKS-acp]→6-[5-hydroxy-3-oxo-2-(3,5,7-trioxooctanoyl)phenyl]-3,5-dioxohexanoyl-[PKS-acp] + H2O |
| No genes |
| 6-[5-hydroxy-3-oxo-2-(3,5,7-trioxooctanoyl)phenyl]-3,5-dioxohexanoyl-[PKS-acp]→2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp] + 2 H2O |
| No genes |
| 2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp] + dioxygen→2-oxo-2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp] + H2O |
| No genes |
| 2-oxo-2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp] + NADPH + H+→(2S)-2-hydroxy-2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp] + NADP+ |
| No genes |
| (2S)-2-hydroxy-2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp]→(4S)-2-acetyl-3,4,8,10,11,12-hexahydroxy-1,4-dihydrotetracen-1-one + H+ + a holo acp domain within a [polyketide synthase] |
| No genes |
| (4S)-2-acetyl-3,4,8,10,11,12-hexahydroxy-1,4-dihydrotetracen-1-one + 2 NADPH + dioxygen + 3 H+→4-demethylpremithracinone + 2 NADP+ + H2O |
| No genes |
| 4-demethylpremithracinone + S-adenosyl-L-methionine→premithracinone + S-adenosyl-L-homocysteine + H+ |
| No genes |
| premithracinone + dTDP-α-D-olivose→premithramycin A1 + H+ + dTDP |
| No genes |
| premithramycin A1 + dTDP-α-D-oliose→premithramycin A2 + H+ + dTDP |
| No genes |
| premithramycin A2 + dTDP-α-D-mycarose→9-demethylpremithramycin A3 + H+ + dTDP |
| No genes |
| 9-demethylpremithramycin A3 + S-adenosyl-L-methionine→premithramycin A3 + S-adenosyl-L-homocysteine + H+ |
| No genes |
| dTDP-α-D-olivose + premithramycin A3→3A-deolivosylpremithramycin B + H+ + dTDP |
| No genes |
| dTDP-α-D-olivose + 3A-deolivosylpremithramycin B→premithramycin B + H+ + dTDP |
| No genes |
| premithramycin B + NADPH + dioxygen + H+→premithramycin B lactone + NADP+ + H2O |
| No genes |
| premithramycin B lactone + H2O→mithramycin DK + CO2 (spontaneous) |
| No genes |
| mithramycin DK + NADPH + H+→mithramycin + NADP+ |
| ABID97_RS15815 |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information