MetaCyc Pathway: glutathione-mediated detoxification II in Variovorax sp. OAS795

Add experiment(s):


Glutathione transferase:
RX + glutathione→a glutathione-S-conjugate + HX
(EC 2.5.1.18)
ABID97_RS00290
ABID97_RS00905
ABID97_RS02045
ABID97_RS02885
ABID97_RS06585
ABID97_RS10130
ABID97_RS10240
ABID97_RS10440
ABID97_RS12400
ABID97_RS14430
ABID97_RS14560
ABID97_RS15785
ABID97_RS19305
ABID97_RS21270
ABID97_RS21420
ABID97_RS24745
ABID97_RS27350
ABID97_RS27770
a glutathione-S-conjugate[in] + ATP[in] + H2O[in]→a glutathione-S-conjugate[out] + ADP[in] + H+[in] + phosphate[in] (EC 7.6.2.3)
No genes
a glutathione-S-conjugate + H2O→a [γ-glutamyl-L-cysteine]-S-conjugate + glycine (EC 3.4.17.25)
No genes
a glutathione-S-conjugate + H2O→an (L-cysteinylglycine)-S-conjugate + L-glutamate (EC 3.4.19.13)
No genes
a [γ-glutamyl-L-cysteine]-S-conjugate + H2O→an L-cysteine-S-conjugate + L-glutamate (EC 3.4.13.M2)
No genes
an (L-cysteinylglycine)-S-conjugate + H2O→an L-cysteine-S-conjugate + glycine (EC 3.4.13.23)
No genes
an L-cysteine-S-conjugate + malonyl-CoA→an N-malonyl-L-cysteine-S-conjugate + coenzyme A + H+
No genes
Cysteine-S-conjugate beta-lyase:
an L-cysteine-S-conjugate + H2O→a thiol + ammonium + pyruvate
(EC 4.4.1.13)
No genes
Thiol S-methyltransferase:
a thiol + S-adenosyl-L-methionine→a methyl thioether + S-adenosyl-L-homocysteine + H+
(EC 2.1.1.9)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information