MetaCyc Pathway: 4-hydroxybenzoate biosynthesis III (plants) in Variovorax sp. OAS795

MetaCyc Pathway: 4-hydroxybenzoate biosynthesis III (plants) in Variovorax sp. OAS795

4-coumarate--CoA ligase:
4-coumarate + ATP + coenzyme A→(E)-4-coumaroyl-CoA + AMP + diphosphate (EC 6.2.1.12)

(E)-4-coumaroyl-CoA + H₂O→3S-(4-hydroxyphenyl)-3-hydroxy-propanoyl-CoA (EC 4.1.2.61)

3-hydroxyacyl-CoA dehydrogenase:
3S-(4-hydroxyphenyl)-3-hydroxy-propanoyl-CoA + NAD⁺→3-(4-hydroxyphenyl)-3-oxo-propanoyl-CoA + NADH + H⁺ (EC 1.1.1.35)

Acetyl-CoA C-acyltransferase (in reverse):
3-(4-hydroxyphenyl)-3-oxo-propanoyl-CoA + coenzyme A→4-hydroxybenzoyl-CoA + acetyl-CoA (EC 2.3.1.16)

4-hydroxybenzoyl-CoA thioesterase:
4-hydroxybenzoyl-CoA + H₂O→4-hydroxybenzoate + coenzyme A + H⁺ (EC 3.1.2.23)

Links:

Pathway details at MetaCyc
Fitness data for 30 genes
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All MetaCyc pathways for Variovorax sp. OAS795

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information