MetaCyc Pathway: serotonin degradation in Variovorax sp. OAS795

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Aryl sulfotransferase:
serotonin + 3'-phosphoadenylyl-sulfate→serotonin O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Monoamine oxidase:
serotonin + dioxygen + H2O→5-hydroxyindole acetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
5-hydroxyindole acetaldehyde + L-cysteine→5-hydroxyindole thiazolidine carboxylate + H+ + H2O (spontaneous)
No genes
Aldehyde dehydrogenase (NAD(+)):
5-hydroxyindole acetaldehyde + NAD+ + H2O→5-hydroxyindole acetate + NADH + 2 H+ (EC 1.2.1.3)
ABID97_RS01290
ABID97_RS04070
ABID97_RS06830
ABID97_RS09960
ABID97_RS10380
ABID97_RS13510
ABID97_RS13535
ABID97_RS15020
ABID97_RS18885
ABID97_RS22830
ABID97_RS25410
ABID97_RS25710
ABID97_RS25990
ABID97_RS26110
ABID97_RS28560
ABID97_RS28760
ABID97_RS29450
Alcohol dehydrogenase (in reverse):
5-hydroxyindole acetaldehyde + NADH + H+→5-hydroxytryptophol + NAD+ (EC 1.1.1.1)
ABID97_RS10235
ABID97_RS13195
ABID97_RS13275
ABID97_RS15955
ABID97_RS18840
ABID97_RS25565
ABID97_RS27980
ABID97_RS29150
ABID97_RS29360
Aryl sulfotransferase:
5-hydroxytryptophol + 3'-phosphoadenylyl-sulfate→5-hydroxytryptophol sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Glucuronosyltransferase:
5-hydroxytryptophol + UDP-α-D-glucuronate→5-hydroxytryptophol glucuronide + H+ + UDP (EC 2.4.1.17)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information