MetaCyc Pathway: phenazine-1-carboxylate biosynthesis in Variovorax sp. OAS795

Add experiment(s):


2-amino-4-deoxychorismate synthase (in reverse):
chorismate + L-glutamine→(2S)-2-amino-4-deoxy-chorismate + L-glutamate
(EC 2.6.1.86)
No genes
(2S)-2-amino-4-deoxy-chorismate + H2O→(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate + pyruvate (EC 3.3.2.15)
No genes
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate→(1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate (EC 5.3.3.17)
No genes
2 (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate→(1R,5aS,6R)-4a-hydroxy-1,4,4a,5,5a,6,9,10a-octahydrophenazine-1,6-dicarboxylate + 2 H+ + H2O
No genes
(1R,5aS,6R)-4a-hydroxy-1,4,4a,5,5a,6,9,10a-octahydrophenazine-1,6-dicarboxylate→(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H2O
No genes
(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + dioxygen→(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + hydrogen peroxide (EC 1.10.3.16)
ABID97_RS21325
(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + dioxygen + H+→(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + hydrogen peroxide (spontaneous)
No genes
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + dioxygen→(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + hydrogen peroxide (EC 1.10.3.16)
ABID97_RS21325
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + dioxygen→(10aS)-10,10a-dihydrophenazine-1-carboxylate + hydrogen peroxide (EC 1.10.3.16)
ABID97_RS21325
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate→(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate (spontaneous)
No genes
(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate→5,10-dihydrophenazine-1,6-dicarboxylate (spontaneous)
No genes
(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + dioxygen→(10aS)-10,10a-dihydrophenazine-1-carboxylate + hydrogen peroxide (EC 1.10.3.16)
ABID97_RS21325
(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + dioxygen + H+→5,10-dihydrophenazine + CO2 + hydrogen peroxide (spontaneous)
No genes
5,10-dihydrophenazine-1,6-dicarboxylate + dioxygen→phenazine-1,6-dicarboxylate + hydrogen peroxide (spontaneous)
No genes
(10aS)-10,10a-dihydrophenazine-1-carboxylate→5,10-dihydrophenazine-1-carboxylate (spontaneous)
No genes
5,10-dihydrophenazine + dioxygen→phenazine + hydrogen peroxide (spontaneous)
No genes
5,10-dihydrophenazine-1-carboxylate + dioxygen→phenazine-1-carboxylate + hydrogen peroxide (spontaneous)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information