MetaCyc Pathway: catechol degradation II (meta-cleavage pathway) in Variovorax sp. OAS795

Add experiment(s):


Catechol 2,3-dioxygenase:
catechol + dioxygen→(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H+
(EC 1.13.11.2)
ABID97_RS26345
ABID97_RS27995
(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + NAD+ + H2O→(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH + 2 H+ (EC 1.2.1.85)
No genes
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate→(3E)-2-oxohex-3-enedioate (EC 5.3.2.6)
ABID97_RS03050
ABID97_RS26260
4-oxalocrotonate decarboxylase:
(3E)-2-oxohex-3-enedioate + H+→(2Z)-2-hydroxypenta-2,4-dienoate + CO2
(EC 4.1.1.77)
ABID97_RS27935
2-oxopent-4-enoate hydratase (in reverse):
(2Z)-2-hydroxypenta-2,4-dienoate + H2O→(S)-4-hydroxy-2-oxopentanoate
(EC 4.2.1.80)
ABID97_RS15830
ABID97_RS27940
4-hydroxy-2-oxovalerate aldolase:
(S)-4-hydroxy-2-oxopentanoate→acetaldehyde + pyruvate
(EC 4.1.3.39)
ABID97_RS27920
Acetaldehyde dehydrogenase (acetylating):
acetaldehyde + coenzyme A + NAD+→acetyl-CoA + NADH + H+
(EC 1.2.1.10)
ABID97_RS27925

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information