MetaCyc Pathway: benzoyl-CoA degradation I (aerobic) in Variovorax sp. OAS795

MetaCyc Pathway: benzoyl-CoA degradation I (aerobic) in Variovorax sp. OAS795

benzoyl-CoA + NADPH + dioxygen + H⁺→2,3-epoxy-2,3-dihydrobenzoyl-CoA + NADP⁺ + H₂O (EC 1.14.13.208)

2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H₂O→cis-3,4-dehydroadipyl-CoA semialdehyde + formate + H⁺ (EC 4.1.2.44)

cis-3,4-dehydroadipyl-CoA semialdehyde + NADP⁺ + H₂O→cis-3,4-dehydroadipyl-CoA + NADPH + 2 H⁺ (EC 1.2.1.77)

cis-3,4-dehydroadipyl-CoA→(2E)-5-carboxy-2-pentenoyl-CoA

No genes

Enoyl-CoA hydratase (in reverse):
(2E)-5-carboxy-2-pentenoyl-CoA + H₂O→(3S)-hydroxyadipyl-CoA (EC 4.2.1.17)

3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD⁺→3-oxoadipoyl-CoA + NADH + H⁺ (EC 1.1.1.35)

3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA (EC 2.3.1.174)

Links:

Pathway details at MetaCyc
Fitness data for 40 genes
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All MetaCyc pathways for Variovorax sp. OAS795

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information