MetaCyc Pathway: phosphopantothenate biosynthesis I in Variovorax sp. OAS795

3-methyl-2-oxobutanoate hydroxymethyltransferase:
3-methyl-2-oxobutanoate + a 5,10-methylenetetrahydrofolate + H₂O→2-dehydropantoate + a tetrahydrofolate (EC 2.1.2.11)

ABID97_RS07435

2-dehydropantoate 2-reductase (in reverse):
2-dehydropantoate + NADPH + H⁺→(R)-pantoate + NADP⁺ (EC 1.1.1.169)

ABID97_RS00870

Pantoate--beta-alanine ligase:
(R)-pantoate + β-alanine + ATP→(R)-pantothenate + AMP + diphosphate + H⁺ (EC 6.3.2.1)

ABID97_RS07430

Pantothenate kinase:
(R)-pantothenate + ATP→(R)-4'-phosphopantothenate + ADP + H⁺ (EC 2.7.1.33)

ABID97_RS00230

ABID97_RS00825

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Pathway details at MetaCyc
Fitness data for 12 genes
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All MetaCyc pathways for Variovorax sp. OAS795

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information