MetaCyc Pathway: tetrahydrofolate biosynthesis I in Sphingobium sp. HT1-2

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Dihydropteroate synthase:
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate→7,8-dihydropteroate + diphosphate
(EC 2.5.1.15)
GFF1988
GFF5329
Dihydrofolate synthase:
7,8-dihydropteroate + ATP + L-glutamate→7,8-dihydrofolate monoglutamate + ADP + H+ + phosphate
(EC 6.3.2.12)
GFF1629
Dihydrofolate reductase (in reverse):
a 7,8-dihydrofolate + NADPH + H+→a tetrahydrofolate + NADP+
(EC 1.5.1.3)
GFF1297
GFF1574

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information