MetaCyc Pathway: tetrapyrrole biosynthesis II (from glycine) in Rhizobium sp. OAE497

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5-aminolevulinate synthase:
glycine + H+ + succinyl-CoA→5-aminolevulinate + CO2 + coenzyme A (EC 2.3.1.37)
ABIE40_RS17760
ABIE40_RS20880
Porphobilinogen synthase:
2 5-aminolevulinate→porphobilinogen + H+ + 2 H2O (EC 4.2.1.24)
ABIE40_RS06690
Hydroxymethylbilane synthase:
4 porphobilinogen + H2O→preuroporphyrinogen + 4 ammonium (EC 2.5.1.61)
ABIE40_RS18065
Uroporphyrinogen-III synthase:
preuroporphyrinogen→uroporphyrinogen-III + H2O (EC 4.2.1.75)
ABIE40_RS18070

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information