MetaCyc Pathway: nicotinate degradation I in Pseudomonas putida KT2440

Add experiment(s):


nicotinate + 2 an oxidized cytochrome + H2O→6-hydroxynicotinate + 2 H+ + 2 a reduced cytochrome (EC 1.17.2.1)
PP_3947
PP_3948
6-hydroxynicotinate + NADH + dioxygen + 2 H+→2,5-dihydroxypyridine + CO2 + NAD+ + H2O (EC 1.14.13.114)
PP_3944
2,5-dihydroxypyridine 5,6-dioxygenase:
2,5-dihydroxypyridine + dioxygen→N-formylmaleamate + H+ (EC 1.13.11.9)
PP_3945
N-formylmaleamate + H2O→maleamate + formate + H+ (EC 3.5.1.106)
PP_3943
maleamate + H2O→maleate + ammonium (EC 3.5.1.107)
PP_3941
Maleate isomerase:
maleate→fumarate (EC 5.2.1.1)
PP_3942

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information