MetaCyc Pathway: superpathway of L-tyrosine biosynthesis in Pseudomonas putida KT2440

3-deoxy-7-phosphoheptulonate synthase: D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)

PP_1866

PP_2324

PP_3080

3-dehydroquinate synthase: 3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)

PP_5078

3-dehydroquinate dehydratase: 3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)

PP_0560

PP_1612

PP_2407

PP_3003

Shikimate dehydrogenase (in reverse): 3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)

PP_0074

PP_2406

PP_2608

PP_3002

PP_3768

Shikimate kinase: shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)

PP_5079

3-phosphoshikimate 1-carboxyvinyltransferase: shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)

PP_1770

Chorismate synthase: 5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)

PP_1830

Chorismate mutase: chorismate→prephenate (EC 5.4.99.5)

PP_1769

Prephenate dehydrogenase: prephenate + NAD+→3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (EC 1.3.1.12)

PP_1770

Aspartate transaminase (in reverse): 3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)

PP_0486

PP_0858

PP_0967

PP_1109

PP_1872

PP_1972

PP_2642

PP_2948

PP_3544

PP_3590

PP_3750

PP_3786

PP_4197

PP_5275

PP_5342

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information