MetaCyc Pathway: 4-hydroxybenzoate biosynthesis III (plants) in Pseudomonas putida KT2440

4-coumarate--CoA ligase: 4-coumarate + ATP + coenzyme A→(E)-4-coumaroyl-CoA + AMP + diphosphate (EC 6.2.1.12)

PP_3356

(E)-4-coumaroyl-CoA + H2O→3S-(4-hydroxyphenyl)-3-hydroxy-propanoyl-CoA (EC 4.1.2.61)

PP_3358

3-hydroxyacyl-CoA dehydrogenase: 3S-(4-hydroxyphenyl)-3-hydroxy-propanoyl-CoA + NAD+→3-(4-hydroxyphenyl)-3-oxo-propanoyl-CoA + NADH + H+ (EC 1.1.1.35)

PP_2047

PP_2136

Acetyl-CoA C-acyltransferase (in reverse): 3-(4-hydroxyphenyl)-3-oxo-propanoyl-CoA + coenzyme A→4-hydroxybenzoyl-CoA + acetyl-CoA (EC 2.3.1.16)

PP_0582

PP_1377

PP_2051

PP_2137

PP_2215

PP_3280

PP_3355

PP_3754

PP_4636

4-hydroxybenzoyl-CoA thioesterase: 4-hydroxybenzoyl-CoA + H2O→4-hydroxybenzoate + coenzyme A + H+ (EC 3.1.2.23)

PP_1218

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information