MetaCyc Pathway: catechol degradation III (ortho-cleavage pathway) in Pseudomonas putida KT2440

Catechol 1,2-dioxygenase: catechol + dioxygen→cis,cis-muconate + 2 H+ (EC 1.13.11.1)

PP_3166

PP_3713

Muconate cycloisomerase (in reverse): cis,cis-muconate + H+→(+)-muconolactone (EC 5.5.1.1)

PP_3715

Muconolactone Delta-isomerase: (+)-muconolactone→(4,5-dihydro-5-oxofuran-2-yl)-acetate (EC 5.3.3.4)

PP_3714

3-oxoadipate enol-lactonase: (4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O→3-oxoadipate + H+ (EC 3.1.1.24)

PP_1380

PP_3645

PP_4540

3-oxoadipate CoA-transferase: 3-oxoadipate + succinyl-CoA→3-oxoadipoyl-CoA + succinate (EC 2.8.3.6)

PP_3951

PP_3952

3-oxoadipyl-CoA thiolase (in reverse): 3-oxoadipoyl-CoA + coenzyme A→acetyl-CoA + succinyl-CoA (EC 2.3.1.174)

PP_1377

PP_3280

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information