MetaCyc Pathway: superpathway of coenzyme A biosynthesis I (bacteria) in Pseudomonas putida KT2440

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3-methyl-2-oxobutanoate hydroxymethyltransferase:
3-methyl-2-oxobutanoate + a 5,10-methylenetetrahydrofolate + H2O→2-dehydropantoate + a tetrahydrofolate (EC 2.1.2.11)
PP_4699
Aspartate 1-decarboxylase:
L-aspartate + H+→β-alanine + CO2 (EC 4.1.1.11)
No genes
2-dehydropantoate 2-reductase (in reverse):
2-dehydropantoate + NADPH + H+→(R)-pantoate + NADP+ (EC 1.1.1.169)
PP_1351
PP_2325
PP_2998
PP_4678
Pantoate--beta-alanine ligase:
β-alanine + (R)-pantoate + ATP→(R)-pantothenate + AMP + diphosphate + H+ (EC 6.3.2.1)
PP_4700
Pantothenate kinase:
(R)-pantothenate + ATP→(R)-4'-phosphopantothenate + ADP + H+ (EC 2.7.1.33)
PP_0438
Phosphopantothenate--cysteine ligase:
(R)-4'-phosphopantothenate + CTP + L-cysteine→(R)-4'-phosphopantothenoyl-L-cysteine + CMP + diphosphate + H+ (EC 6.3.2.5)
PP_5285
Phosphopantothenoylcysteine decarboxylase:
(R)-4'-phosphopantothenoyl-L-cysteine + H+→4'-phosphopantetheine + CO2 (EC 4.1.1.36)
PP_5285
Pantetheine-phosphate adenylyltransferase:
4'-phosphopantetheine + ATP + H+→3'-dephospho-CoA + diphosphate (EC 2.7.7.3)
PP_5123
Dephospho-CoA kinase:
3'-dephospho-CoA + ATP→coenzyme A + ADP + H+ (EC 2.7.1.24)
PP_0631

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information