GTP cyclohydrolase I:
GTP + H2O→7,8-dihydroneopterin 3'-triphosphate + formate + H+ (EC 3.5.4.16) |
| OH686_00635 |
| OH686_18765 |
6-pyruvoyltetrahydropterin synthase:
7,8-dihydroneopterin 3'-triphosphate→(6R)-6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate (EC 4.2.3.12) |
| OH686_00030 |
Sepiapterin reductase (in reverse):
(6R)-6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH + H+→(6R)-6-lactoyl-5,6,7,8-tetrahydropterin + NADP+ (EC 1.1.1.153; 1.1.1.220; 1.1.1.325) |
| No genes |
| (6R)-6-lactoyl-5,6,7,8-tetrahydropterin + NADPH + H+→(6R)-L-threo-5,6,7,8-tetrahydrobiopterin + NADP+ (EC 1.1.1.325) |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information