MetaCyc Pathway: pyruvate decarboxylation to acetyl CoA I in Pseudomonas sp. RS175

a [pyruvate dehydrogenase E2 protein] N⁶-dihydrolipoyl-L-lysine + NAD⁺→a [pyruvate dehydrogenase E2 protein] N⁶-lipoyl-L-lysine + NADH + H⁺ (EC 1.2.1.104; 1.8.1.4)

PFR28_02448

PFR28_03094

PFR28_04545

a [pyruvate dehydrogenase E2 protein] N⁶-lipoyl-L-lysine + pyruvate + H⁺→a [pyruvate dehydrogenase E2 protein] N⁶-S-acetyldihydrolipoyl-L-lysine + CO₂ (EC 1.2.1.104; 1.2.4.1)

a [pyruvate dehydrogenase E2 protein] N⁶-S-acetyldihydrolipoyl-L-lysine + coenzyme A→a [pyruvate dehydrogenase E2 protein] N⁶-dihydrolipoyl-L-lysine + acetyl-CoA (EC 1.2.1.104; 2.3.1.12)

PFR28_01771

PFR28_05060

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Pathway details at MetaCyc
Fitness data for 9 genes
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All MetaCyc pathways for Pseudomonas sp. RS175

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information