MetaCyc Pathway: lipid IVA biosynthesis (generic) in Pseudomonas sp. RS175

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Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase:
UDP-N-acetyl-α-D-glucosamine + a (3R)-3-hydroxyacyl-[acyl-carrier protein]→UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-α-D-glucosamine + a soluble [acyl-carrier protein] (EC 2.3.1.129)
PFR28_00408
UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-α-D-glucosamine + H2O→UDP-3-O-[(3R)-3-hydroxyacyl]-α-D-glucosamine + acetate (EC 3.5.1.108)
PFR28_03581
UDP-3-O-[(3R)-3-hydroxyacyl]-α-D-glucosamine + a (3R)-3-hydroxyacyl-[acyl-carrier protein]→UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-α-D-glucosamine + a soluble [acyl-carrier protein] + H+ (EC 2.3.1.191)
PFR28_00406
UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-α-D-glucosamine + H2O→a lipid X + 2 H+ + UMP (EC 3.6.1.54)
PFR28_02746
Lipid-A-disaccharide synthase:
a lipid X + UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-α-D-glucosamine→a lipid A disaccharide + H+ + UDP (EC 2.4.1.182)
PFR28_00409
Tetraacyldisaccharide 4'-kinase:
a lipid A disaccharide + ATP→a lipid IVA + ADP + H+ (EC 2.7.1.130)
PFR28_03028

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information