MetaCyc Pathway: 2-oxoglutarate decarboxylation to succinyl-CoA in Pseudomonas sp. RS175

a [2-oxoglutarate dehydrogenase E2 protein] N⁶-lipoyl-L-lysine + 2-oxoglutarate + H⁺→a [2-oxoglutarate dehydrogenase E2 protein] N⁶-S-succinyldihydrolipoyl-L-lysine + CO₂ (EC 1.2.1.105; 1.2.4.2)

PFR28_03096

a [2-oxoglutarate dehydrogenase E2 protein] N⁶-S-succinyldihydrolipoyl-L-lysine + coenzyme A→a [2-oxoglutarate dehydrogenase E2 protein] N⁶-dihydrolipoyl-L-lysine + succinyl-CoA (EC 1.2.1.105; 2.3.1.61)

PFR28_03095

a [2-oxoglutarate dehydrogenase E2 protein] N⁶-dihydrolipoyl-L-lysine + NAD⁺→a [2-oxoglutarate dehydrogenase E2 protein] N⁶-lipoyl-L-lysine + NADH + H⁺ (EC 1.2.1.105; 1.8.1.4)

PFR28_02448

PFR28_03094

PFR28_04545

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Pathway details at MetaCyc
Fitness data for 5 genes
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All MetaCyc pathways for Pseudomonas sp. RS175

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information