MetaCyc Pathway: 8-amino-7-oxononanoate biosynthesis I in Pseudomonas fluorescens SBW25

Add experiment(s):


a malonyl-[acp] + S-adenosyl-L-methionine→a malonyl-[acp] methyl ester + S-adenosyl-L-homocysteine (EC 2.1.1.197)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase II:
a malonyl-[acp] + a malonyl-[acp] methyl ester + H+→a 3-oxoglutaryl-[acp] methyl ester + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
PFLU_RS02075
PFLU_RS02090
PFLU_RS09030
PFLU_RS15160
PFLU_RS15590
PFLU_RS23045
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxoglutaryl-[acp] methyl ester + NADPH + H+→a (3R)-3-hydroxyglutaryl-[acp] methyl ester + NADP+ (EC 1.1.1.100)
PFLU_RS02080
PFLU_RS03220
PFLU_RS05335
PFLU_RS05340
PFLU_RS09615
PFLU_RS09635
PFLU_RS09805
PFLU_RS09810
PFLU_RS12555
PFLU_RS14865
PFLU_RS14960
PFLU_RS15050
PFLU_RS15565
PFLU_RS15990
PFLU_RS16275
PFLU_RS17200
PFLU_RS18190
PFLU_RS19495
PFLU_RS22760
PFLU_RS22960
PFLU_RS23055
PFLU_RS30525
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyglutaryl-[acp] methyl ester→a (2E)-enoylglutaryl-[acp] methyl ester + H2O (EC 4.2.1.59)
PFLU_RS06330
PFLU_RS09035
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-enoylglutaryl-[acp] methyl ester + NADH + H+→a glutaryl-[acp] methyl ester + NAD+ (EC 1.3.1.9)
PFLU_RS14490
Beta-ketoacyl-acyl-carrier-protein synthase II:
a glutaryl-[acp] methyl ester + a malonyl-[acp] + H+→a 3-oxopimeloyl-[acp] methyl ester + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
PFLU_RS02075
PFLU_RS02090
PFLU_RS09030
PFLU_RS15160
PFLU_RS15590
PFLU_RS23045
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxopimeloyl-[acp] methyl ester + NADPH + H+→a (3R)-3-hydroxypimeloyl-[acp] methyl ester + NADP+ (EC 1.1.1.100)
PFLU_RS02080
PFLU_RS03220
PFLU_RS05335
PFLU_RS05340
PFLU_RS09615
PFLU_RS09635
PFLU_RS09805
PFLU_RS09810
PFLU_RS12555
PFLU_RS14865
PFLU_RS14960
PFLU_RS15050
PFLU_RS15565
PFLU_RS15990
PFLU_RS16275
PFLU_RS17200
PFLU_RS18190
PFLU_RS19495
PFLU_RS22760
PFLU_RS22960
PFLU_RS23055
PFLU_RS30525
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxypimeloyl-[acp] methyl ester→a (2E)-enoylpimeloyl-[acp] methyl ester + H2O (EC 4.2.1.59)
PFLU_RS06330
PFLU_RS09035
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-enoylpimeloyl-[acp] methyl ester + NADH + H+→a pimeloyl-[acp] methyl ester + NAD+ (EC 1.3.1.9)
PFLU_RS14490
a pimeloyl-[acp] methyl ester + H2O→a pimeloyl-[acp] + methanol + H+ (EC 3.1.1.85)
No genes
8-amino-7-oxononanoate synthase:
a pimeloyl-[acp] + L-alanine + H+→(8S)-8-amino-7-oxononanoate + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.47)
PFLU_RS27645

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information