MetaCyc Pathway: aromatic compounds degradation via β-ketoadipate in Pseudomonas fluorescens SBW25

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Catechol 1,2-dioxygenase:
catechol + dioxygencis,cis-muconate + 2 H+
(EC 1.13.11.1)
PFLU_RS25470
Protocatechuate 3,4-dioxygenase:
protocatechuate + dioxygen→3-carboxy-cis,cis-muconate + 2 H+
(EC 1.13.11.3)
PFLU_RS06740
PFLU_RS06745
3-carboxy-cis,cis-muconate cycloisomerase (in reverse):
3-carboxy-cis,cis-muconate + H+→(2-carboxy-2,5-dihydro-5-oxofuran-2-yl)-acetate
(EC 5.5.1.2)
PFLU_RS06755
PFLU_RS12375
Muconate cycloisomerase (in reverse):
cis,cis-muconate + H+→(+)-muconolactone
(EC 5.5.1.1)
PFLU_RS25480
4-carboxymuconolactone decarboxylase:
(2-carboxy-2,5-dihydro-5-oxofuran-2-yl)-acetate + H+→(4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2
(EC 4.1.1.44)
PFLU_RS04275
PFLU_RS06765
Muconolactone Delta-isomerase:
(+)-muconolactone→(4,5-dihydro-5-oxofuran-2-yl)-acetate
(EC 5.3.3.4)
PFLU_RS25475
3-oxoadipate enol-lactonase:
(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O→3-oxoadipate + H+
(EC 3.1.1.24)
PFLU_RS06760
PFLU_RS09135
PFLU_RS11540
PFLU_RS17240
PFLU_RS22225
3-oxoadipate CoA-transferase:
3-oxoadipate + succinyl-CoA→3-oxoadipoyl-CoA + succinate
(EC 2.8.3.6)
PFLU_RS06725
PFLU_RS06730
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→acetyl-CoA + succinyl-CoA
(EC 2.3.1.174)
PFLU_RS06735

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information