MetaCyc Pathway: ceramide degradation by α-oxidation in Paraburkholderia sabiae LMG 24235

Add experiment(s):


a phytoceramide + 2 a ferrocytochrome b5 + dioxygen + 2 H+→a (2'R)-2'-hydroxy-phytoceramide + 2 a ferricytochrome b5 + H2O (EC 1.14.18.6)
No genes
Ceramidase:
a (2'R)-2'-hydroxy-phytoceramide + H2O→a (2R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acid + a phytosphingosine
(EC 3.5.1.23)
No genes
a (2R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acid + ATP + coenzyme A→a (R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acyl CoA + AMP + diphosphate
No genes
a (R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acyl CoA→formyl-CoA + an odd numbered straight chain 2,3,4-saturated fatty aldehyde (EC 4.1.2.63)
No genes
Formyl-CoA hydrolase:
formyl-CoA + H2O→formate + coenzyme A + H+
(EC 3.1.2.10)
No genes
Aldehyde dehydrogenase (NAD(+)):
an odd numbered straight chain 2,3,4-saturated fatty aldehyde + NAD+ + H2O→an odd numbered straight chain 2,3,4-saturated fatty acid + NADH + 2 H+
(EC 1.2.1.3)
QEN71_RS00050
QEN71_RS07095
QEN71_RS11040
QEN71_RS11670
QEN71_RS13660
QEN71_RS14810
QEN71_RS16945
QEN71_RS19510
QEN71_RS20195
QEN71_RS20440
QEN71_RS20790
QEN71_RS21070
QEN71_RS23580
QEN71_RS24925
QEN71_RS27500
QEN71_RS28765
QEN71_RS31880
QEN71_RS31965
QEN71_RS32565
QEN71_RS34295
QEN71_RS35780
QEN71_RS37085
QEN71_RS38180
QEN71_RS38780
QEN71_RS39635
QEN71_RS40180
QEN71_RS41285
QEN71_RS42030
Long-chain-fatty-acid--CoA ligase:
an odd numbered straight chain 2,3,4-saturated fatty acid + ATP + coenzyme A→an odd numbered straight chain 2,3,4-saturated fatty acyl CoA + AMP + diphosphate
(EC 6.2.1.3)
QEN71_RS22975
QEN71_RS27455
QEN71_RS29275
QEN71_RS37010

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information