MetaCyc Pathway: dTMP de novo biosynthesis (mitochondrial) in Paraburkholderia sabiae LMG 24235

Dihydrofolate reductase (in reverse): a 7,8-dihydrofolate + NADPH + H+→a tetrahydrofolate + NADP+ (EC 1.5.1.3)

QEN71_RS04275

QEN71_RS20955

QEN71_RS28605

Glycine hydroxymethyltransferase: a tetrahydrofolate + L-serine→a 5,10-methylenetetrahydrofolate + glycine + H2O (EC 2.1.2.1)

QEN71_RS08310

QEN71_RS11055

QEN71_RS26235

QEN71_RS33600

QEN71_RS34010

QEN71_RS34315

QEN71_RS35520

Thymidylate synthase: a 5,10-methylenetetrahydrofolate + dUMP→a 7,8-dihydrofolate + dTMP (EC 2.1.1.45)

QEN71_RS00815

QEN71_RS04325

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information