MetaCyc Pathway: aspartate superpathway in Paraburkholderia sabiae LMG 24235

Add experiment(s):


Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate
(EC 2.6.1.1)
QEN71_RS00075
QEN71_RS02890
QEN71_RS03175
QEN71_RS03275
QEN71_RS06560
QEN71_RS08880
QEN71_RS10500
QEN71_RS12205
QEN71_RS12215
QEN71_RS13030
QEN71_RS17025
QEN71_RS18160
QEN71_RS18375
QEN71_RS20720
QEN71_RS21505
QEN71_RS22410
QEN71_RS23125
QEN71_RS23470
QEN71_RS24010
QEN71_RS24645
QEN71_RS30710
QEN71_RS31640
QEN71_RS32300
QEN71_RS36905
QEN71_RS38860
QEN71_RS38900
QEN71_RS38970
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP
(EC 2.7.2.4)
QEN71_RS06150
L-aspartate oxidase:
L-aspartate + dioxygen→2-iminosuccinate + hydrogen peroxide + H+
(EC 1.4.3.16)
QEN71_RS03070
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate
(EC 1.2.1.11)
QEN71_RS17625
Quinolinate synthase:
2-iminosuccinate + glycerone phosphate→quinolinate + phosphate + 2 H2O
(EC 2.5.1.72)
QEN71_RS03060
L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7)
QEN71_RS05940
QEN71_RS11050
QEN71_RS20640
QEN71_RS30495
QEN71_RS34275
QEN71_RS35845
QEN71_RS35895
QEN71_RS39630
QEN71_RS41290
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+
(EC 1.1.1.3)
QEN71_RS22405
Nicotinate-nucleotide diphosphorylase (carboxylating) (in reverse):
quinolinate + 2 H+ + 5-phospho-α-D-ribose 1-diphosphate→β-nicotinate D-ribonucleotide + CO2 + diphosphate
(EC 2.4.2.19)
QEN71_RS03065
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+
(EC 2.7.1.39)
QEN71_RS17850
Homoserine O-succinyltransferase:
L-homoserine + succinyl-CoA→O-succinyl-L-homoserine + coenzyme A
(EC 2.3.1.46)
QEN71_RS42530
Nicotinate-nucleotide adenylyltransferase:
β-nicotinate D-ribonucleotide + ATP + H+→nicotinate adenine dinucleotide + diphosphate
(EC 2.7.7.18)
QEN71_RS24410
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+→(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ + H2O (EC 1.17.1.8)
QEN71_RS26970
NAD(+) synthase (glutamine-hydrolyzing):
nicotinate adenine dinucleotide + ATP + L-glutamine + H2O→NAD+ + AMP + L-glutamate + diphosphate + H+
(EC 6.3.5.1)
QEN71_RS24895
NAD(+) synthase:
nicotinate adenine dinucleotide + ammonium + ATP→NAD+ + AMP + diphosphate + H+
(EC 6.3.1.5)
QEN71_RS18870
QEN71_RS21235
QEN71_RS24895
Cystathionine gamma-synthase:
O-succinyl-L-homoserine + L-cysteine→L-cystathionine + H+ + succinate
(EC 2.5.1.48)
QEN71_RS05200
QEN71_RS17685
QEN71_RS38310
QEN71_RS42510
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase:
(S)-2,3,4,5-tetrahydrodipicolinate + succinyl-CoA + H2ON-succinyl-2-amino-6-ketopimelate + coenzyme A
(EC 2.3.1.117)
QEN71_RS06365
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate
(EC 4.2.3.1)
QEN71_RS18575
QEN71_RS22400
QEN71_RS40245
QEN71_RS40295
QEN71_RS41235
Cysteine-S-conjugate beta-lyase:
L-cystathionine + H2O→L-homocysteine + ammonium + pyruvate
(EC 4.4.1.13)
No genes
Succinyldiaminopimelate transaminase (in reverse):
N-succinyl-2-amino-6-ketopimelate + L-glutamateN-succinyl-L,L-2,6-diaminopimelate + 2-oxoglutarate
(EC 2.6.1.17)
QEN71_RS03130
QEN71_RS04065
QEN71_RS06370
QEN71_RS23375
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase:
L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate
(EC 2.1.1.14)
QEN71_RS19725
Methionine synthase:
L-homocysteine + a 5-methyltetrahydrofolate→L-methionine + a tetrahydrofolate
(EC 2.1.1.13)
QEN71_RS01190
QEN71_RS01195
Succinyl-diaminopimelate desuccinylase:
N-succinyl-L,L-2,6-diaminopimelate + H2O→L,L-diaminopimelate + succinate
(EC 3.5.1.18)
QEN71_RS06355
QEN71_RS22065
Diaminopimelate epimerase:
L,L-diaminopimelate→meso-diaminopimelate
(EC 5.1.1.7)
QEN71_RS00365
QEN71_RS03330
QEN71_RS08005
QEN71_RS25975
Methionine adenosyltransferase:
L-methionine + ATP + H2OS-adenosyl-L-methionine + diphosphate + phosphate
(EC 2.5.1.6)
QEN71_RS00375
Diaminopimelate decarboxylase:
meso-diaminopimelate + H+→L-lysine + CO2
(EC 4.1.1.20)
QEN71_RS28080

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information