MetaCyc Pathway: pheomelanin biosynthesis in Paraburkholderia sabiae LMG 24235

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Monophenol monooxygenase:
L-tyrosine + dioxygen→dopaquinone + H2O (EC 1.14.18.1)
QEN71_RS19355
dopaquinone + L-cysteine→5-S-cysteinyldopa (spontaneous)
No genes
dopaquinone + L-cysteine→2-S-cysteinyldopa (spontaneous)
No genes
2-S-cysteinyldopa + dopaquinone→2-S-cysteinyldopaquinone + L-dopa (spontaneous)
No genes
5-S-cysteinyldopa + dopaquinone→5-S-cysteinyldopaquinone + L-dopa (spontaneous)
No genes
5-S-cysteinyldopaquinone→7-[(2S)-2-amino-2-carboxylatoethyl]-5-hydroxy-2H-1,4-benzothiazine-3-carboxylate + H+ + H2O (spontaneous)
No genes
2-S-cysteinyldopaquinone→8-[(2S)-2-amino-2-carboxylatoethyl]-5-hydroxy-2H-1,4-benzothiazine-3-carboxylate + H+ + H2O (spontaneous)
No genes
7-[(2S)-2-amino-2-carboxylatoethyl]-5-hydroxy-2H-1,4-benzothiazine-3-carboxylate + 8-[(2S)-2-amino-2-carboxylatoethyl]-5-hydroxy-2H-1,4-benzothiazine-3-carboxylate→pheomelanin
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information