MetaCyc Pathway: serotonin degradation in Paraburkholderia sabiae LMG 24235

Add experiment(s):


Aryl sulfotransferase:
serotonin + 3'-phosphoadenylyl-sulfate→serotonin O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Monoamine oxidase:
serotonin + dioxygen + H2O→5-hydroxyindole acetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
5-hydroxyindole acetaldehyde + L-cysteine→5-hydroxyindole thiazolidine carboxylate + H+ + H2O (spontaneous)
No genes
Aldehyde dehydrogenase (NAD(+)):
5-hydroxyindole acetaldehyde + NAD+ + H2O→5-hydroxyindole acetate + NADH + 2 H+ (EC 1.2.1.3)
QEN71_RS00050
QEN71_RS07095
QEN71_RS11040
QEN71_RS11670
QEN71_RS13660
QEN71_RS14810
QEN71_RS16945
QEN71_RS19510
QEN71_RS20195
QEN71_RS20440
QEN71_RS20790
QEN71_RS21070
QEN71_RS23580
QEN71_RS24925
QEN71_RS27500
QEN71_RS28765
QEN71_RS31880
QEN71_RS31965
QEN71_RS32565
QEN71_RS34295
QEN71_RS35780
QEN71_RS37085
QEN71_RS38180
QEN71_RS38780
QEN71_RS39635
QEN71_RS40180
QEN71_RS41285
QEN71_RS42030
Alcohol dehydrogenase (in reverse):
5-hydroxyindole acetaldehyde + NADH + H+→5-hydroxytryptophol + NAD+ (EC 1.1.1.1)
QEN71_RS02555
QEN71_RS07550
QEN71_RS08075
QEN71_RS12765
QEN71_RS33145
QEN71_RS37215
QEN71_RS38175
Aryl sulfotransferase:
5-hydroxytryptophol + 3'-phosphoadenylyl-sulfate→5-hydroxytryptophol sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Glucuronosyltransferase:
5-hydroxytryptophol + UDP-α-D-glucuronate→5-hydroxytryptophol glucuronide + H+ + UDP (EC 2.4.1.17)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information