MetaCyc Pathway: ethylmalonyl-CoA pathway in Paraburkholderia sabiae LMG 24235

Add experiment(s):


Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
QEN71_RS01125
QEN71_RS02070
QEN71_RS14170
QEN71_RS15980
QEN71_RS18320
QEN71_RS18730
QEN71_RS21880
QEN71_RS22175
QEN71_RS22200
QEN71_RS22970
QEN71_RS27505
Acetoacetyl-CoA reductase (in reverse):
acetoacetyl-CoA + NADPH + H+→(3R)-3-hydroxybutanoyl-CoA + NADP+ (EC 1.1.1.36)
QEN71_RS22195
QEN71_RS32115
3-hydroxybutyryl-CoA dehydratase:
(3R)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.55)
QEN71_RS08410
QEN71_RS32940
QEN71_RS36175
crotonyl-CoA + CO2 + NADPH→(2S)-ethylmalonyl-CoA + NADP+ (EC 1.3.1.85)
No genes
Methylmalonyl-CoA epimerase:
(2S)-ethylmalonyl-CoA→(2R)-ethylmalonyl-CoA (EC 5.1.99.1)
No genes
(2R)-ethylmalonyl-CoA→(2S)-methylsuccinyl-CoA (EC 5.4.99.63)
No genes
(2S)-methylsuccinyl-CoA + an oxidized electron-transfer flavoprotein + H+→2-methylfumaryl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.12)
No genes
2-methylfumaryl-CoA + H2O→(2R,3S)-β-methylmalyl-CoA (EC 4.2.1.148)
No genes
Malyl-CoA lyase:
(2R,3S)-β-methylmalyl-CoA→glyoxylate + propanoyl-CoA (EC 4.1.3.24)
QEN71_RS12140
QEN71_RS19830
QEN71_RS33980
Malyl-CoA lyase (in reverse):
acetyl-CoA + glyoxylate→(S)-malyl-CoA (EC 4.1.3.24)
QEN71_RS12140
QEN71_RS19830
QEN71_RS33980
Malate--CoA ligase (in reverse):
(S)-malyl-CoA + ADP + phosphate→(S)-malate + ATP + coenzyme A (EC 6.2.1.9)
QEN71_RS33990
QEN71_RS33995

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information