MetaCyc Pathway: (<i>S</i>)-reticuline biosynthesis I in Paraburkholderia sabiae LMG 24235

MetaCyc Pathway: (S)-reticuline biosynthesis I in Paraburkholderia sabiae LMG 24235

Monophenol monooxygenase:
2 L-tyrosine + dioxygen→2 L-dopa (EC 1.14.18.1)

Aspartate transaminase:
L-tyrosine + 2-oxoglutarate→3-(4-hydroxyphenyl)pyruvate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)

Tyrosine decarboxylase:
L-tyrosine + H⁺→tyramine + CO₂ (EC 4.1.1.25; 4.1.1.28)

4-hydroxyphenylpyruvate decarboxylase:
3-(4-hydroxyphenyl)pyruvate + H⁺→(4-hydroxyphenyl)acetaldehyde + CO₂ (EC 4.1.1.80)

No genes

Tyrosine 3-monooxygenase:
tyramine + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + dioxygen→dopamine + 4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin (EC 1.14.16.2)

No genes

Aromatic-L-amino-acid decarboxylase:
L-dopa + H⁺→dopamine + CO₂ (EC 4.1.1.28)

(S)-norcoclaurine synthase:
dopamine + (4-hydroxyphenyl)acetaldehyde→(S)-norcoclaurine + H₂O (EC 4.2.1.78)

No genes

(RS)-norcoclaurine 6-O-methyltransferase:
(S)-norcoclaurine + S-adenosyl-L-methionine→(S)-coclaurine + S-adenosyl-L-homocysteine + H⁺ (EC 2.1.1.128)

No genes

(S)-coclaurine-N-methyltransferase:
(S)-coclaurine + S-adenosyl-L-methionine→(S)-N-methylcoclaurine + S-adenosyl-L-homocysteine + H⁺ (EC 2.1.1.140)

No genes

(S)-N-methylcoclaurine + dioxygen + a reduced [NADPH-hemoprotein reductase]→(S)-3'-hydroxy-N-methylcoclaurine + an oxidized [NADPH-hemoprotein reductase] + H₂O (EC 1.14.14.102)

No genes

3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase:
(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine→(S)-reticuline + S-adenosyl-L-homocysteine + H⁺ (EC 2.1.1.116)

No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information